Geurink, Paul P.: search on Z-Library

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1

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V.,

Journal:

Year:

2013

Language:

english

File:

PDF, 4.10 MB

english, 2013

2

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 2.22 MB

english, 2019

3

Poly(ethylene glycol)-Based Stable Isotope Labeling Reagents for the Quantitative Analysis of Low Molecular Weight Metabolites by LC−MS

Abello, Nicolas, Geurink, Paul P., Toorn, Marco van der, Oosterhout, Antoon J. M. van, Lugtenburg, Johan, Marel, Gijs A. van der, Kerstjens, Huib A. M., Postma, Dirkje S., Overkleeft, Hermen S., Bisch

Journal:

Analytical Chemistry

Year:

2008

Language:

english

File:

PDF, 725 KB

english, 2008

4

[Methods in Enzymology] || Profiling DUBs and Ubl-specific proteases with activity-based probes

Geurink, Paul P.

Year:

2019

Language:

english

File:

PDF, 795 KB

english, 2019

5

Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation

Palmer, Amy L., de Jong, Annemieke, Leestemaker, Yves, Geurink, Paul P., Wijdeven, Ruud H., Ovaa, Huib, Dolan, Brian P.

Journal:

The Journal of Immunology

Year:

2017

Language:

english

File:

PDF, 1.33 MB

english, 2017

6

[Methods in Enzymology] || Profiling DUBs and Ubl-specific proteases with activity-based probes

Geurink, Paul P.

Year:

2019

File:

PDF, 795 KB

2019

7

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim,

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.97 MB

english, 2018

8

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

Dr. Paul P. Geurink, Dr. Farid El Oualid, Anika Jonker, Dharjath S. Hameed, Dr. Huib Ovaa

Journal:

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

9

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Shin, Donghyuk, Mukherjee, Rukmini, Grewe, Diana, Bojkova, Denisa, Baek, Kheewoong, Bhattacharya, Anshu, Schulz, Laura, Widera, Marek, Mehdipour, Ahmad Reza, Tascher, Georg, Geurink, Paul P., Wilhelm,

Journal:

Year:

2020

File:

PDF, 7.03 MB

2020

10

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

Pruneda, Jonathan N., Durkin, Charlotte H., Geurink, Paul P., Ovaa, Huib, Santhanam, Balaji, Holden, David W., Komander, David

Journal:

Year:

2016

Language:

english

File:

PDF, 5.97 MB

english, 2016

11

A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling

Paul P. Geurink, Dr. Bogdan I. Florea, Nan Li, Dr. Martin D. Witte, Joeri Verasdonck, Chi-Lin Kuo, Prof. Dr. Gijs A. van der Marel, Prof. Dr. Herman S. Overkleeft

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 454 KB

english, 2010

12

Functional Proteomics on Zinc-Dependent Metalloproteinases using Inhibitor Probes

Theo Klein, Paul P. Geurink, Hermen S. Overkleeft, Henk K. Kauffman, Rainer Bischoff

Journal:

Year:

2009

Language:

english

File:

PDF, 387 KB

english, 2009

13

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

Geurink, Paul P., van der Linden, Wouter A., Mirabella, Anne C., Gallastegui, Nerea, de Bruin, Gerjan, Blom, Annet E. M., Voges, Mathias J., Mock, Elliot D., Florea, Bogdan I., van der Marel, Gijs A.,

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.86 MB

english, 2013

14

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Mevissen, Tycho E. T., Kulathu, Yogesh, Mulder, Monique P.C., Geurink, Paul P., Maslen, Sarah L., Gersch, Malte, Elliott, Paul R., Burke, John E., van Tol, Bianca D. M., Akutsu, Masato, El Oualid, Far

Journal:

Year:

2016

Language:

english

File:

PDF, 8.87 MB

english, 2016

15

Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors

van der Linden, Wouter A., Geurink, Paul P., Oskam, Chris, van der Marel, Gijsbert A., Florea, Bogdan I., Overkleeft, Herman S.

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 297 KB

english, 2010

16

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

Alex C. Faesen, Mark P.A. Luna-Vargas, Paul P. Geurink, Marcello Clerici, Remco Merkx, Willem J. van Dijk, Dharjath S. Hameed, Farid El Oualid, Huib Ovaa, Titia K. Sixma

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.68 MB

english, 2011

17

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.56 MB

english, 2016

18

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation

Geurink, Paul P, Ovaa, Huib, Xin, Bo-Tao, van Tol, Bianca D.M.

Journal:

Organic & Biomolecular Chemistry

Year:

2018

Language:

english

File:

PDF, 1.07 MB

english, 2018

19

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

Kooij, Raymond, Liu, Sijia, Sapmaz, Aysegul, Xin, Bo-Tao, Janssen, George M. C., van Veelen, Peter A., Ovaa, Huib, ten Dijke, Peter, Geurink, Paul P.

Journal:

Journal of the American Chemical Society

Year:

2020

File:

PDF, 6.21 MB

2020

20

Rapid covalent-probe discovery by electrophile-fragment screening

Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P., Aimon, Anthony, Amitai, Gabriel, Bellini, Dom, Bennett, James, Fairhead, Michael, Fe

Journal:

Journal of the American Chemical Society

Year:

2019

File:

PDF, 1.24 MB

2019

21

Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates

Geurink, Paul P., Florea, Bogdan I., Van der Marel, Gijs A., Kessler, Benedikt M., Overkleeft, Herman S.

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 743 KB

english, 2010

22

A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity-based metalloproteinase profiling protocol

Geurink, Paul, Klein, Theo, Leeuwenburgh, Michiel, van der Marel, Gijs, Kauffman, Henk, Bischoff, Rainer, Overkleeft, Herman

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 267 KB

english, 2008

23

Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach

Li, Jing, Girard, Genevieve, Florea, Bogdan I., Geurink, Paul P., Li, Nan, van der Marel, Gijsbert A., Overhand, Mark, Overkleeft, Herman S., van Wezel, Gilles P.

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 266 KB

english, 2012

24

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

Geurink, Paul P., van Tol, Bianca D. M., van Dalen, Duco, Brundel, Paul J. G., Mevissen, Tycho E. T., Pruneda, Jonathan N., Elliott, Paul R., van Tilburg, Gabriëlle B. A., Komander, David, Ovaa, Huib

Journal:

Year:

2016

Language:

english

File:

PDF, 2.02 MB

english, 2016

25

Structural basis of the specificity of USP18 toward ISG15

Basters, Anja, Geurink, Paul P, Röcker, Annika, Witting, Katharina F, Tadayon, Roya, Hess, Sandra, Semrau, Marta S, Storici, Paola, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter

Journal:

Nature Structural and Molecular Biology

Year:

2017

Language:

english

File:

PDF, 2.93 MB

english, 2017

26

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

Paul P. Geurink, Bogdan I. Florea, Herman S. Overkleeft

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 213 KB

english, 2011

27

Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis

Liu, Sijia, González Prieto, Román, Zhang, Mengdi, Geurink, Paul P, Kooij, Raymond, Iyengar, Prasanna Vasudevan, van Dinther, Maarten, Bos, Erik, Zhang, Xiaobing, Le Dévédec, Sylvia E, van de Water, B

Journal:

Clinical Cancer Research

Year:

2019

File:

PDF, 2.49 MB

2019

28

A MALDI-TOF Approach to Ubiquitin Ligase Activity

van Tol, Bianca D.M., Geurink, Paul P., Ovaa, Huib

Journal:

Cell Chemical Biology

Year:

2018

Language:

english

File:

PDF, 357 KB

english, 2018

29

A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling

Paul P. Geurink, Dr. Bogdan I. Florea, Nan Li, Dr. Martin D. Witte, Joeri Verasdonck, Chi-Lin Kuo, Prof. Dr. Gijs A. van der Marel, Prof. Dr. Herman S. Overkleeft

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 435 KB

english, 2010

30

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

Geurink, Paul P., Liu, Nora, Spaans, Michiel P., Downey, Sondra L., van den Nieuwendijk, Adrianus M. C. H., van der Marel, Gijsbert A., Kisselev, Alexei F., Florea, Bogdan I., Overkleeft, Herman S.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.52 MB

english, 2010

31

Design of Peptide Hydroxamate-Based Photoreactive Activity-Based Probes of Zinc-Dependent Metalloproteases

Paul P. Geurink, Theo Klein, Laurette Prèly, Krisztina Paal, Michiel A. Leeuwenburgh, Gijs A. van der Marel, Henk F. Kauffman, Herman S. Overkleeft, Rainer Bischoff

Journal:

European Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 481 KB

english, 2010

32

Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis

Liu, Sijia, González Prieto, Román, Zhang, Mengdi, Geurink, Paul P, Kooij, Raymond, Iyengar, Prasanna Vasudevan, van Dinther, Maarten, Bos, Erik, Zhang, Xiaobing, Le Dévédec, Sylvia E, van de Water, B

Journal:

Clinical Cancer Research

Year:

2019

Language:

english

File:

PDF, 2.49 MB

english, 2019

33

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, Davi

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 297 KB

english, 2013

34

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15

Basters, Anja, Geurink, Paul P., El Oualid, Farid, Ketscher, Lars, Casutt, Marco S., Krause, Eberhard, Ovaa, Huib, Knobeloch, Klaus-Peter, Fritz, Günter

Journal:

Year:

2014

Language:

english

File:

PDF, 398 KB

english, 2014

35

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

Bogdan I. Florea, Martijn Verdoes, Nan Li, Wouter A. van der Linden, Paul P. Geurink, Hans van den Elst, Tanja Hofmann, Arnoud de Ru, Peter A. van Veelen, Keiji Tanaka, Katsuhiro Sasaki, Shigeo Murata

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 469 KB

english, 2010

36

Solid-Phase Synthesis of Succinylhydroxamate Peptides: Functionalized Matrix Metalloproteinase Inhibitors

Leeuwenburgh, Michiel A., Geurink, Paul P., Klein, Theo, Kauffman, Henk F., van der Marel, Gijs A., Bischoff, Rainer, Overkleeft, Herman S.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 135 KB

english, 2006

37

Catching a DUB in the act: novel ubiquitin-based active site directed probes

Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib

Journal:

Current Opinion in Chemical Biology

Year:

2014

Language:

english

File:

PDF, 492 KB

english, 2014

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